HEALTHY HOLIDAYS FROM VIBE MUSHROOMS

Dwayne N. Jackson, PhD 

Are you ready for a HIGH-VIBE holiday season? We definitely are! For many of us, tis’ the season for work parties, house parties, holiday shopping, getting together with family and friends, and a having a lot of fun—not to mention indulging in great food and perhaps the ‘odd’ drink. 

However, we must not also forget that holiday festivities tend to come with sleep deprivation, stress, poor food choices, and greater exposure to cold and flu viruses. 

Although the internet is riddled with tricks and tips to combat cold and flu, very few have scientific evidence to back their claims. Fortunately, there is an abundance of research illustrating potent antiviral, immunomodulating, and stress relieving efficacy of functional mushroom extracts! 

This season, our goal is to keep you in the middle of all the holiday action and out of the doctor’s office! So, read on to get the science-backed lowdown on how to exploit the immunomodulatory properties of Vibe Mushroom’s Turkey Tail and Red Reishi and enjoy your holidays to the fullest!

Our immune system is vital for survival. Without an immune system, our bodies would be open to attack from bacteria, viruses, parasites, and disease. 

Interestingly, our fungi friends must also deal with many of the same environmental threats that we do! Believe it or not, many fungi have evolved biochemical properties to protect them from bacteria and viruses that colonize them—many of which also infect humans. This has led to an abundance of research studies establishing mushroom extracts, like Vibe’s Turkey Tail and Red Reishi, as potent prophylactics and supportive treatments for viral respiratory infections like cold and flu. 

Beyond cold and flu, functional mushrooms and their extracts have been studied for decades as immune system modulators, including use in immunotherapy, treatment of different types of cancer, and immune regulation in autoimmunity. Past research has shown that bioactive components extracted from certain mushrooms exhibit strong anticancer, antiviral, and anti-inflammatory protection, and prophylactic effects for the liver. Thus, functional mushrooms have great potential for use as successful antiviral treatments with little to no risks of adverse side effects.

Mushrooms to optimize immunity

Through recent research, it is becoming well-known that functional mushrooms possess a plethora of biological and pharmacologically active molecules— many of which, when ingested, have been shown to positively modulate our immune system and provide immunity support.  

Through immunomodulation, pharmaceutical-grade mushroom extracts, like Vibe’s Turkey Tail and Red Reishi, have been shown to provide protection from cold and flu viruses by: 

1. Enhancing body immunity
2. Reducing the viral load in the body 
3. Supporting the efficacy of vaccines 
4. Inhibiting viral replication 

ATTENTION KYLE: PLEASE MAKE A NEW VERSION OF THIS FIGURE (BELOW) WITH IMAGES OF TURKEY TAIL AND RED REISHI MUSHOOM AND REPLACE MOUSE WITH HUMAN BODY

In terms of immunity, the bioactive compounds found in Vibe’s Turkey Tail and Red Reishi may promote and/or support:

• Macrophage activity
• Cytokines associated with innate immunity
• Antibody production
• T lymphocyte production and prevention of decline
• Regeneration of bone marrow cells
• Secretion of human interferons
• Natural killer (NK) cell activity
• Aggressiveness of granulocytes against viruses
• Enhanced activity and production of helper T4 (CD4) lymphocytes

Vibe’s pharmaceutical-grade organic Red Reishi extract has the industry’s highest levels of immunomodulating Beta-D-Glucans, Triterpenoids, Polyphenols, and Ganoderic Acids! 

Adaptogens, like Red Reishi, are metabolic regulators which increase our ability to handle and adapt to stress. Being classified as an adaptogen, the important medicinal compounds found in Vibe Mushroom’s Red Reishi extract have been shown to modulate immunity, provide antiviral and antibacterial support, increase resistance to daily stress, decrease sensitivity to daily stressors, improve relaxation, and promote increased sleep quality. 

To put it simply, Red Reishi enables you to operate and recover at a higher level without getting mentally and physically rundown. 

Our Red Reishi is a 15:1 extraction, so 1 gram of Vibe’s Red Reishi extract has at least 1500 % or 15x greater potency over the best whole Red Reishi mushroom powders available! 

For best results, take 1 to 3 grams daily (0.5 to 1.5 tsp or 2 to 6 capsules), taken all at once in the morning, split up throughout the day, or taken 30-60 minutes before bed. If you use a full 3 grams daily, split it into 3 x 1-gram doses and take throughout the day. 

With our powered format, you can mix it directly into your coffee, tea, yogurt, greens, or smoothies. Because Vibe’s Red Reishi is pharmaceutical-grade potency, the concentrated Ganoderic acids make it taste bitter. Many people enjoy its bitterness, but bitter may not be your thing. If this is the case, we suggest splitting doses or using our capsules. 

Vibe’s pharmaceutical-grade organic Turkey Tail has the industry’s greatest balance of immunomodulating Polysaccharides, Beta-D-Glucans, Polyphenols, and Polysaccharopeptides! 

The unique immunomodulatory compounds found in abundance in Vibe’s Turkey Tail extract are polysaccharopeptides, which are protein-bound polysaccharides. Krestin (PSK) and Polysaccharide Peptide (PSP) are two polysaccharopeptides found in turkey tail, which have been reported to have potent antiviral, antioxidant, and antitumour activities. PSP also acts as a prebiotic and modulates human intestinal microbiome composition, helping the gut regulate its balance of bacteria. Overall, the gut health benefits, antioxidant activity, and anti-inflammatory effects of Turkey Tail make this a great choice if you are looking to improve health and immunity. 

Our Turkey Tail is a 10:1 extraction, so 1 gram of Vibe’s Turkey Tail has at least 1000% or 10x greater potency over the best whole Turkey Tail mushroom powders available! 

For best results, take 1 to 3 grams daily (0.5 to 1.5 tsp or 2 to 6 capsules), taken all at once in the morning, split up throughout the day, or taken 30-60 minutes before bed. If you use a full 3 grams daily, split it into 3 x 1-gram doses and take throughout the day. 

With our powered format, you can mix it directly into your coffee, tea, yogurt, greens, or smoothies. The flavour profile of Vibe Turkey Tail is mild, earthy, and mellow. Many people find it enhances the flavor of coffee and chocolate. 

VIBE’S MAXIMUM MUSHROOM IMMUNITY STACK:

Upon waking: 1/2 g Red Reishi (1 capsule or 1/2 tsp powder) + 1/2 g Turkey Tail (1 capsule or 1/2 tsp powder) on empty stomach or with food

Midday: 1/2 g Red Reishi (1 capsule or 1/2 tsp powder) + 1/2 g Turkey Tail (1 capsule or 1/2 tsp powder) on empty stomach or with food

2-hrs before bed: 1/2 g Red Reishi (1 capsule or 1/2 tsp powder) + 1/2 g Turkey Tail (1 capsule or 1/2 tsp powder) on empty stomach or with food

AN IMPORTANT NOTE ORGANIC PHARMACEUTICAL-GRADE MUSHROOM EXTRACTS: 

The Vibe Mushrooms Difference! 

At Vibe Mushrooms, our organic mushroom extracts are grown and produced under the strict guidelines and specifications of the TCM Pharmacopeia and manufactured under cGMP standards. Based on this, we provide pharmaceutical-grade purity and potency in all our products—a standard that positions well above the best competing brands. We know this because we use 3 independent companies to 3rd party test all our extracts and confirm they meet medicinal standards. In the spirit of full disclosure, you can download these lab reports from our website. 

References: 

Abate M, Pepe G, Randino R, Pisanti S, Basilicata MG, Covelli V, Bifulco M, Cabri W, D’Ursi AM, Campiglia P, Rodriquez M. Ganoderma lucidum Ethanol Extracts Enhance Re-Epithelialization and Prevent Keratinocytes from Free-Radical Injury. Pharmaceuticals (Basel). 2020 Aug 29;13(9):224. 

Wachtel-Galor S., Yuen J., Buswell J.A., Benzie I.F.F. Ganoderma Lucidum (Lingzhi or Reishi) Herbal Medicine: Biomolecular and Clinical Aspects. 2nd ed. Taylor and Francis Group; Milton Park, UK: 2011.

Chu T.T., Benzie I.F., Lam C.W., Fok B.S., Lee K.K., Tomlinson B. Study of potential cardioprotective effects of Ganoderma lucidum (Lingzhi): Results of a controlled human intervention trial. Br. J. Nutr. 2012;107:1017–1027.

Yao, C., Wang, Z., Jiang, H. et al. Ganoderma lucidum promotes sleep through a gut microbiota-dependent and serotonin-involved pathway in mice. Sci Rep 11, 13660 (2021).

Yuen J.W., Gohel M.D. Anticancer effects of Ganoderma lucidum: A review of scientific evidence. Nutr. Cancer. 2005;53:11–17

Wu Y.L., Han F., Luan S.S., Ai R., Zhang P., Li H., Chen L.X. Triterpenoids from Ganoderma lucidum and Their Potential Anti-inflammatory Effects. J. Agric. Food Chem. 2019;67:5147–5158. 

Lu S.Y., Peng X.R., Dong J.R., Yan H., Kong Q.H., Shi Q.Q., Li D.S., Zhou L., Li Z.R., Qiu M.H. Aromatic constituents from Ganoderma lucidum and their neuroprotective and anti-inflammatory activities. Fitoterapia. 2019;134:58–64. 

Bishop, K. S. et al. From 2000 years of Ganoderma lucidum to recent developments in nutraceuticals. Phytochemistry 114, 56–65 (2015).

Cuong V.T., Chen W., Shi J., Zhang M., Yang H., Wang N., Yang S., Li J., Yang P., Fei J. The anti-oxidation and anti-aging effects of Ganoderma lucidum in Caenorhabditis elegans. Exp. Gerontol. 2019;117:99–105. 

Wang J., Cao B., Zhao H., Feng J. Emerging Roles of Ganoderma Lucidum in Anti-Aging. Aging Dis. 2017;8:691–707. 

Bishop K.S., Kao C.H.J., Xu Y., Glucina M.P., Paterson R.R.M., Ferguson L.R. From 2000 years of Ganoderma lucidum to recent developments in nutraceuticals. Phytochemistry. 2015;114:56–65. 

Liang C., Tian D., Liu Y., Li H., Zhu J., Li M., Xin M., Xia J. Review of the molecular mechanisms of Ganoderma lucidum triterpenoids: Ganoderic acids A, C2, D, F, DM, X and Y. Eur. J. Med. Chem. 2019;174:130–141. 

Zhao X.R., Zhang B.J., Deng S., Zhang H.L., Huang S.S., Huo X.K., Wang C., Liu F., Ma X.C. Isolation and identification of oxygenated lanostane-type triterpenoids from the fungus Ganoderma lucidum. Phytochem. Lett. 2016;16:87–91. 

Liu Z., Xing J., Zheng S., Bo R., Luo L., Huang Y., Niu Y., Li Z., Wang D., Hu Y., et al. Ganoderma lucidum polysaccharides encapsulated in liposome as an adjuvant to promote Th1-bias immune response. Carbohydr. Polym. 2016;142:141–148. 

Baby S., Johnson A.J., Govindan B. Secondary metabolites from ganoderma. Phytochemistry. 2015;114:66–101. 

Li L., Wang H.H., Nie X.T., Jiang W.R., Zhang Y.S. Sodium butyrate ameliorates lipopolysaccharide-induced cow mammary epithelial cells from oxidative stress damage and apoptosis. J. Cell. Biochem. 2018;120:2370–2381. 

Kladar N.V., Gavarić N.S., Božin B.N. Ganoderma: Insights into anticancer effects. Eur. J. Cancer Prev. 2016;25:462–471. 

Tang W, Gao Y, Chen G, Gao H, Dai X, Ye J, Chan E, Huang M, Zhou S. A randomized, double-blind and placebo-controlled study of a Ganoderma lucidum polysaccharide extract in neurasthenia. J Med Food. 2005 Spring;8(1):53-8. 

Cui XY, Cui SY, Zhang J, Wang ZJ, Yu B, Sheng ZF, Zhang XQ, Zhang YH. Extract of Ganoderma lucidum prolongs sleep time in rats. J Ethnopharmacol. 2012 Feb 15;139(3):796-800. 

Chu QP, Wang LE, Cui XY, Fu HZ, Lin ZB, Lin SQ, Zhang YH. Extract of Ganoderma lucidum potentiates pentobarbital-induced sleep via a GABAergic mechanism. Pharmacol Biochem Behav. 2007 Apr;86(4):693-8. 

Lee I., Ahn B., Choi J., Hattori M., Min B., Bae K. Selective cholinesterase inhibition by lanostane triterpenes from fruiting bodies of Ganoderma lucidum. Bioorganic Med. Chem. Lett. 2011;21:6603–6607.

Collins, R.A.; Ng, T.B. Polysaccharopeptide from Coriolus versicolor has potential for use against human immunodeficiency virus type 1 infection. Life Sci. 1997, 60, PL383–PL387.

Fritz H, Kennedy DA, Ishii M, Fergusson D, Fernandes R, Cooley K, Seely D. Polysaccharide K and Coriolus versicolor extracts for lung cancer: a systematic review. Integr Cancer Ther. 2015;14(3):201–211.